Abstract: In this paper, the mission and the thermal environment of the Solar Close Observations and Proximity Experiments (SCOPE) spacecraft are analyzed, and an advanced thermal management system (ATMS) is designed for it. The relationship and functions of the integrated database, the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon. For the complex thermal field regulation system and extreme space thermal environment, a modular simulation and thermal field planning method are proposed, and the feasibility of the planning algorithm is verified by numerical simulation. A solar array liquid cooling system is developed, and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion. The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.