Abstract: According to the high spatial resolution reconstruction algorithm of the 1m New Vacuum Solar Telescope (NVST) of the Fuxian-Lake Solar Observation Station, the effects of anisoplanatism on speckle interferometry and speckle masking are analyzed theoretically. The observed photosphere data is processed in different sub-sizes and different images are acquired. By comparing power spectrum of the reconstruction images and the reconstruction phase, the impact of the anisoplanatism on the reconstructed results is analyzed. The anisoplanatism limits the effectiveness of speckle interferometry and speckle masking. When the size of the reconstructed area exceeds the size of the isoplanatic region, the accuracy of the amplitude and phase reconstruction is reduced due to the failure of the algorithm. Finally, combined with the specific circumstances of the image processing program, the suggestion of further optimization of the algorithm is provided.